Hiroshi Shigematsu Selected Research

N- (2- (4- (5H- dibenzo(a,d)cyclohepten- 5- yliden)piperidino)ethyl)- 1- formyl- 4- piperidinecarboxamide (AT 1015)

3/2004

AT-1015, a novel serotonin2A receptor antagonist, improves resaturation of exercised ischemic muscle in hypercholesterolemic rabbits.

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Hiroshi Shigematsu Research Topics

Disease

8	Aneurysm (Aneurysms) 01/2013 - 09/2004
6	Ischemia 07/2019 - 09/2003
6	Peripheral Arterial Disease 01/2019 - 04/2002
6	Aortic Aneurysm (Aneurysm, Aortic) 01/2014 - 01/2008
4	Abdominal Aortic Aneurysm 01/2010 - 09/2004
3	Thoracic Aortic Aneurysm 01/2013 - 12/2008
3	Hyperplasia 08/2003 - 04/2002
2	Chronic Renal Insufficiency 07/2019 - 01/2019
2	Chronic Limb-Threatening Ischemia 07/2019 - 08/2003
2	Type 2 Diabetes Mellitus (MODY) 08/2018 - 01/2012
2	Arteriosclerosis Obliterans 01/2016 - 01/2010
2	Stroke (Strokes) 06/2013 - 05/2012
2	Thrombosis (Thrombus) 05/2012 - 12/2010
2	False Aneurysm (Pseudoaneurysm) 08/2011 - 01/2010
2	Hypercholesterolemia 10/2010 - 03/2004
1	Heart Diseases (Heart Disease) 01/2019
1	Atherosclerosis 01/2016
1	Ischemic Stroke 05/2012
1	Aortic Arch Aneurysm 08/2011
1	Cerebral Infarction 08/2011
1	Pneumonia (Pneumonitis) 08/2011
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 08/2011
1	Renal Insufficiency (Renal Failure) 08/2011
1	Esophageal Fistula 07/2011
1	Ulcer 01/2011
1	Rupture 06/2010
1	Heart Arrest (Cardiac Arrest) 06/2010
1	Breast Neoplasms (Breast Cancer) 06/2010
1	Aortic Rupture 06/2010
1	Infections 06/2010
1	Thoracoabdominal Aortic Aneurysm 04/2010
1	Peripheral Arterial Occlusive Disease 1 02/2010
1	Popliteal Artery Entrapment Syndrome 01/2010
1	Thromboembolism 01/2010
1	Arterial Occlusive Diseases (Arterial Occlusive Disease) 01/2010
1	Disease Progression 01/2010
1	Vascular Diseases (Vascular Disease) 05/2009
1	Neoplasms (Cancer) 04/2009
1	Venous Thrombosis (Deep-Vein Thrombosis) 04/2009
1	Paraplegia (Spastic Paraplegia) 12/2008
1	Intermittent Claudication 01/2008
1	Fistula 01/2008
1	Arteriovenous Fistula 01/2008
1	Obesity 07/2007
1	Hemorrhagic Disorders (Hemorrhagic Diathesis) 08/2005

Drug/Important Bio-Agent (IBA)

3	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 09/2004 - 01/2004
2	LipidsIBA 08/2018 - 01/2012
2	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2017 - 01/2016
2	CholesterolIBA 10/2010 - 07/2007
1	anagliptinIBA 08/2018
1	Clopidogrel (Plavix)FDA Link 01/2012
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2012
1	Ezetimibe (Zetia)FDA Link 01/2012
1	Ticlopidine (Ticlid)FDA LinkGeneric 01/2012
1	SolutionsIBA 08/2011
1	Indocyanine Green (Cardio-Green)FDA LinkGeneric 08/2011
1	1- (5- Isoquinolinesulfonyl)- 2- Methylpiperazine (H 7)IBA 01/2011
1	oxidized low density lipoproteinIBA 10/2010
1	Simvastatin (Zocor)FDA LinkGeneric 10/2010
1	Alprostadil (Muse)FDA LinkGeneric 02/2010
1	phenyl-2-aminoethyl sulfide (PAES)IBA 01/2010
1	Adenosine Triphosphate (ATP)IBA 05/2009
1	Hormones (Hormone)IBA 04/2009
1	Serotonin 5-HT2 Receptor AntagonistsIBA 01/2008
1	sarpogrelateIBA 01/2008
1	fibrinmonomerIBA 08/2005
1	Polyethylene Terephthalates (Polyethylene Terephthalate)IBA 08/2005
1	Fibrinogen (Factor I)FDA Link 08/2005
1	GelatinIBA 08/2005
1	Thrombin FDA Link 08/2005
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2004
1	Adenosine (Adenocard)FDA LinkGeneric 07/2004
1	salicylhydroxamic acid (SHAM)IBA 07/2004
1	N- (2- (4- (5H- dibenzo(a,d)cyclohepten- 5- yliden)piperidino)ethyl)- 1- formyl- 4- piperidinecarboxamide (AT 1015)IBA 03/2004
1	Oxygen (Dioxygen)IBA 03/2004
1	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 03/2004
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2004

Therapy/Procedure

9	Stents 01/2014 - 04/2002
7	Therapeutics 01/2019 - 04/2009
5	Endovascular Aneurysm Repair 07/2011 - 01/2008
3	Surgical Amputation (Amputations) 07/2019 - 09/2003
2	Aftercare (After-Treatment) 08/2011 - 09/2004
2	Thrombectomy 12/2010 - 01/2010
2	Endovascular Procedures 12/2008 - 08/2003
2	Ligation 01/2008 - 03/2004
1	Glycemic Control 08/2018
1	Secondary Prevention 06/2013
1	Lasers (Laser) 08/2011
1	Tracheostomy 08/2011
1	Catheters 12/2010
1	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 06/2010
1	Mastectomy (Mammectomy) 06/2010
1	Radiotherapy 06/2010
1	Sternotomy 05/2010
1	Thoracotomy 05/2010
1	Surgical Drapes 01/2010
1	Drug Therapy (Chemotherapy) 04/2009
1	Bed Rest (Bedrest) 04/2009
1	Gastrectomy 01/2008
1	Prostheses and Implants (Prosthesis) 08/2005